HCID 23030470, compound → 6-Iodoquinazolin-4-one

HRID 1767156Notes

Reaction equation

HRID 1767156 reaction equation
[I:1][C:2]1[CH:10]=[C:6]([C:7]([O-])=[O:8])[C:5]([NH2:11])=[CH:4][CH:3]=1.[NH4+:12].[CH:13]([O-])([O-])OC>CO>[I:1][C:2]1[CH:10]=[C:6]2[C:5](=[CH:4][CH:3]=1)[N:11]=[CH:13][NH:12][C:7]2=[O:8]

Participants

4

Reactant 2

HCID 23030470HCID 23030470, compoundHCID 53629101Methylorthoformate

Product 1

HCID 1354016666-Iodoquinazolin-4-oneYield 77.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a 2-mL volume stainless steel pressure-resistant vessel were placed 530 mg (1.9 mmol) of ammonium 5-iodoanthranilate (prepared in the same manner as in Reference Example 4), 403 mg (3.8 mmol) of methyl orthoformate, and 1.5 mL of methanol. The reaction was carried out at 120° C. for 2 hours. After the reaction was complete, the reaction mixture was cooled to room temperature and analyzed (according to absolute quantitative analysis) by high performance liquid chromatography. There was produced 402 mg (reaction yield: 77%) of 6-iodoquinazolin-4-one.

Workup

  1. customIn a 2-mL volume stainless steel pressure-resistant vessel were placed

Sources & evidence

ORD record
ord-34392f6d71094927894e1692f32feda2
Source dataset
uspto-grants-2007_06
Patent number
US07232903B2

Reaction notes

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