HCID 23030470, compound → 6-Iodoquinazolin-4-one

Participants

Reaction Steps

In a 2-mL volume glass vessel equipped with a reflux condenser were placed 530 mg (1.9 mmol) of ammonium 5-iodoanthranilate (prepared in the same manner as in Reference Example 4), 403 mg (3.8 mmol) of methyl orthoformate, and 1.5 mL of n-butyl alcohol. The reaction was carried out at 120° C. for 2 hours. After the reaction was complete, the reaction mixture was cooled to room temperature and analyzed (according to absolute quantitative analysis) by high performance liquid chromatography. There was produced 350 mg (reaction yield: 67%) of 6-iodoquinazolin-4-one.

Provenance & Evidence