HCID 69508090, compound → Benzoic acid, 3-[2-[2-(phenylmethoxy)phenyl]-1-cyclopenten-1-yl]-

HRID 1767189Notes

Reaction equation

HRID 1767189 reaction equation
C([O:3][C:4](=[O:30])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]2[CH2:15][CH2:14][CH2:13][C:12]=2[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[O:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:6]=1)C>CO>[CH2:23]([O:22][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=1[C:12]1[CH2:13][CH2:14][CH2:15][C:11]=1[C:7]1[CH:6]=[C:5]([CH:10]=[CH:9][CH:8]=1)[C:4]([OH:30])=[O:3])[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

3

Reactant 1

HCID 69508090HCID 69508090, compound

Product 1

HCID 10215735Benzoic acid, 3-[2-[2-(phenylmethoxy)phenyl]-1-cyclopenten-1-yl]-

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3-[2-(2-Benzyloxyphenyl)-cyclopent-1-enyl] benzoic acid ethyl ester (120 mg) was refluxed for 1 h in methanol/2N sodium hydroxide (10/10 mL). The reaction mixture was then evaporated down to 3 mL on a rotary evaporator. 2N Hydrochloric acid was added. The product was extracted with dichloromethane (2×10 mL), dried over magnesium sulphate and evaporated down to an oil which solidified on standing (wt: 100 mg).

Workup

  1. customThe reaction mixture was then evaporated down to 3 mL on a rotary evaporator
  2. addition2N Hydrochloric acid was added
  3. extractionThe product was extracted with dichloromethane (2×10 mL)
  4. dry with materialdried over magnesium sulphate
  5. customevaporated down to an oil which

Sources & evidence

ORD record
ord-a4c86c9e25dc44e69838c7e2438ac3de
Source dataset
uspto-grants-2007_06
Patent number
US07232821B2

Reaction notes

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