HCID 58887630, compound → HCID 21112938, compound

Participants

Reaction Steps

3-{2-[5-Bromo-2-(methoxy)-phenyl]-cyclopent-1-enyl}-benzoic acid ethyl ester (416 mg, 10.0 mmol) in dichloromethane (5 mL) was cooled under nitrogen to ˜40° C. and was treated with a molar solution of borontribromide in dichloromethane (20 mL, 20.0 mmol). The reaction mixture was then allowed to reach room temperature and kept stirring over night. The reaction mixture was then quenched with ice/water (50/50 mL) and more dichloromethane (30 mL) was added. After stirring vigorously for 1.5 hr. the organic layer was separated, dried (magnesium sulphate), evaporated down and chromatographed with 1% methanol in dichloromethane to give (300 mg, 80%).

Provenance & Evidence