反应详情

5-{2-[5-Chloro-2-(4-chlorobenzyloxy)-phenyl]-cyclopent-1-enyl}-nicotinic acid ethyl ester (90 mg) was hydrolysed in methanol (3 mL) and 2N sodium hydroxide (2 mL) at 60° C. with stirring for 2 hrs. The reaction mixture was then reduced down to ˜1 mL, diluted with water (10 mL) and treated with a few drops of glacial acetic acid to make the solution ˜pH5. The product was then extracted twice with dichloromethane (10 mL) dried (magnesium sulphate), and evaporated to give the title compound (75 mg).

1. extractionThe product was then extracted twice with dichloromethane (10 mL)
2. dry with materialdried (magnesium sulphate)
3. customevaporated