Sodium methanethiolate → HCID 21112946, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of sodium methanethiolate (700 mg, 10 mmol) and (3-{2-[5-methylsulfanyl-2-(methoxy-)-phenyl]-cyclopent-1-enyl}-benzoic acid ethyl ester (720 mg, 1.96 mmol) in dimethylformamide (15 ml) was stirred and heated at 120° C. under nitrogen for 5 hours. After cooling the mixture was diluted with diethyl ether/water and the aqueous phase separated and acidified with hydrochloric acid then extracted with diethyl ether. The organic phase was dried (MgSO4), evaporated to dryness and the residue triturated with diethyl ether/iso-hexane to yield the title compound as a white solid, (437 mg, 68%).

Provenance & Evidence