2-Benzyloxy-5-trifluoromethylphenylboronic acid → 6-{2-[5-Trifluoromethyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}-pyridine-2-carboxylic Acid Methyl Ester

HRID 1767221Notes

Reaction equation

HRID 1767221 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]2[CH2:15][CH2:14][CH2:13][C:12]=2Br)[N:6]=1)=[O:4].[CH2:17]([O:24][C:25]1[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][C:26]=1B(O)O)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]2[CH2:15][CH2:14][CH2:13][C:12]=2[C:26]2[CH:27]=[C:28]([C:31]([F:34])([F:33])[F:32])[CH:29]=[CH:30][C:25]=2[O:24][CH2:17][C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[N:6]=1)=[O:4]

Participants

3

Reactant 2

HCID 230053392-Benzyloxy-5-trifluoromethylphenylboronic acidHCID 695080786-(2-Bromocyclopent-1-enyl)-pyridine-2-carboxylic acid methyl ester

Product 1

HCID 695078406-{2-[5-Trifluoromethyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}-pyridine-2-carboxylic Acid Methyl Ester

Procedure

Prepared by general procedure 3 but using 6-(2-bromocyclopent-1enyl)pyridine-2-carboxylic acid methyl ester instead of 3-(2-bromocyclopent-1-enyl)benzoic acid ethyl ester and 2-benzyloxy-5-trifluoromethylphenylboronic acid instead of 5-chloro-2-methoxyphenylboronic acid.

Workup

  1. customPrepared by general procedure 3

Sources & evidence

ORD record
ord-f35f76ee88db464198e3d191d42ec832
Source dataset
uspto-grants-2007_06
Patent number
US07232821B2

Reaction notes

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