2-Benzyloxy-5-trifluoromethylphenylboronic acid → 3-{2-[5-Trifluoromethyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}-6-aminobenzoic acid ethyl ester

HRID 1767224Notes

Reaction equation

HRID 1767224 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][C:10]=1B(O)O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:22]([O:24][C:25](=[O:39])[C:26]1[C:31]([NH2:32])=[CH:30][CH:29]=[C:28]([C:33]2[CH2:37][CH2:36][CH2:35][C:34]=2Br)[CH:27]=1)[CH3:23]>>[CH2:22]([O:24][C:25](=[O:39])[C:26]1[C:31]([NH2:32])=[CH:30][CH:29]=[C:28]([C:33]2[CH2:37][CH2:36][CH2:35][C:34]=2[C:10]2[CH:11]=[C:12]([C:15]([F:18])([F:17])[F:16])[CH:13]=[CH:14][C:9]=2[O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH:27]=1)[CH3:23]

Participants

3

Reactant 2

HCID 230053392-Benzyloxy-5-trifluoromethylphenylboronic acidHCID 695077973-(2-Bromocyclopent-1-enyl)-6-aminobenzoic acid ethyl ester

Product 1

HCID 695077703-{2-[5-Trifluoromethyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}-6-aminobenzoic acid ethyl ester

Procedure

Prepared by general procedure C(iii) but using 2-benzyloxy-5-trifluoromethylphenylboronic acid instead of 2-benzyloxy-5-chlorophenylboronic acid and 3-(2-bromocyclopent-1-enyl)-6-aminobenzoic acid ethyl ester instead of 3-(2-bromo-cyclopent-1-enyl)-6-methylbenzoic acid ethyl ester.

Workup

  1. customPrepared by general procedure C(iii)

Sources & evidence

ORD record
ord-8bc28151d278436b8513f675859c50f5
Source dataset
uspto-grants-2007_06
Patent number
US07232821B2

Reaction notes

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