2-(Benzyloxy)-5-bromophenylboronic acid → 3-{2-[5-Bromo-2-(benzyloxy)phenyl]cyclopent-1-enyl}-5-aminobenzoic acid methyl ester

HRID 1767230Notes

Reaction equation

HRID 1767230 reaction equation
[CH3:1][O:2][C:3](=[O:17])[C:4]1[CH:9]=[C:8]([C:10]2[CH2:14][CH2:13][CH2:12][C:11]=2Br)[CH:7]=[C:6]([NH2:16])[CH:5]=1.[CH2:18]([O:25][C:26]1[CH:31]=[CH:30][C:29]([Br:32])=[CH:28][C:27]=1B(O)O)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH3:1][O:2][C:3](=[O:17])[C:4]1[CH:5]=[C:6]([NH2:16])[CH:7]=[C:8]([C:10]2[CH2:14][CH2:13][CH2:12][C:11]=2[C:27]2[CH:28]=[C:29]([Br:32])[CH:30]=[CH:31][C:26]=2[O:25][CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:9]=1

Participants

3

Reactant 2

HCID 211129242-(Benzyloxy)-5-bromophenylboronic acidHCID 588876693-Amino-5-(2-bromocyclopent-1-enyl)benzoic acid methyl ester

Product 1

HCID 695076593-{2-[5-Bromo-2-(benzyloxy)phenyl]cyclopent-1-enyl}-5-aminobenzoic acid methyl ester

Procedure

Prepared by general procedure 3 but using 3-amino-5-(2-bromocyclopent-1-enyl)benzoic acid methyl ester instead of 3-(2-bromocyclopent-1-enyl)benzoic acid ethyl ester and 2-(benzyloxy)-5-bromophenylboronic acid instead of 5-chloro-2-methoxyphenylboronic acid.

Workup

  1. customPrepared by general procedure 3

Sources & evidence

ORD record
ord-2bab84da6fdd4de48d471483aafd5eeb
Source dataset
uspto-grants-2007_06
Patent number
US07232821B2

Reaction notes

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