4-Fluorobenzyl bromide → HCID 69507983, compound

HRID 1767233Notes

Reaction equation

HRID 1767233 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([OH:27])=[C:6]([C:8]2[CH2:12][CH2:11][CH2:10][C:9]=2[C:13]2[CH:14]=[C:15]([NH:22][C:23](=[O:26])[CH2:24][CH3:25])[CH:16]=[C:17]([CH:21]=2)[C:18]([OH:20])=[O:19])[CH:7]=1.[F:28][C:29]1[CH:36]=[CH:35][C:32]([CH2:33]Br)=[CH:31][CH:30]=1>CC(C)=O>[F:28][C:29]1[CH:36]=[CH:35][C:32]([CH2:33][O:19][C:18](=[O:20])[C:17]2[CH:21]=[C:13]([C:9]3[CH2:10][CH2:11][CH2:12][C:8]=3[C:6]3[CH:7]=[C:2]([F:1])[CH:3]=[CH:4][C:5]=3[O:27][CH2:33][C:32]3[CH:35]=[CH:36][C:29]([F:28])=[CH:30][CH:31]=3)[CH:14]=[C:15]([NH:22][C:23](=[O:26])[CH2:24][CH3:25])[CH:16]=2)=[CH:31][CH:30]=1

Participants

4

Reactant 2

HCID 680214-Fluorobenzyl bromideHCID 21112982HCID 21112982, compound

Product 1

HCID 69507983HCID 69507983, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Prepared by general procedure 5 but using 5-[2-(5-fluoro-2-hydroxyphenyl)cyclopent-1-enyl]-3-(propionamido)benzoic acid instead of 6-[2-(5-chloro-2-hydroxyphenyl)cyclopent-1-enyl]pyridine-2 carboxylic acid, 4-fluorobenzyl bromide instead of 4-chlorobenzyl bromide and acetone instead of 2-butanone.

Workup

  1. customPrepared by general procedure 5

Sources & evidence

ORD record
ord-21703d96aed64d22a8627c8b0253a253
Source dataset
uspto-grants-2007_06
Patent number
US07232821B2

Reaction notes

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