4-Fluorobenzyl bromide → HCID 69508177, compound

HRID 1767234Notes

Reaction equation

HRID 1767234 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[C:9]1[CH2:13][CH2:12][CH2:11][C:10]=1[C:14]1[CH:15]=[C:16]([NH:23][C:24](=[O:27])[CH2:25][CH3:26])[CH:17]=[C:18]([CH:22]=1)[C:19]([OH:21])=[O:20].[F:28][C:29]1[CH:36]=[CH:35][C:32]([CH2:33]Br)=[CH:31][CH:30]=1>CC(C)=O>[F:28][C:29]1[CH:36]=[CH:35][C:32]([CH2:33][O:20][C:19](=[O:21])[C:18]2[CH:22]=[C:14]([C:10]3[CH2:11][CH2:12][CH2:13][C:9]=3[C:3]3[CH:4]=[C:5]([CH3:8])[CH:6]=[CH:7][C:2]=3[O:1][CH2:33][C:32]3[CH:35]=[CH:36][C:29]([F:28])=[CH:30][CH:31]=3)[CH:15]=[C:16]([NH:23][C:24](=[O:27])[CH2:25][CH3:26])[CH:17]=2)=[CH:31][CH:30]=1

Participants

4

Reactant 2

HCID 680214-Fluorobenzyl bromideHCID 21112964HCID 21112964, compound

Product 1

HCID 69508177HCID 69508177, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Prepared by general procedure 5 but using 5-[2-(2-hydroxy-5-methylphenyl)cyclopent-1-enyl]-3-(propionamido)benzoic acid instead of 6-[2-(5-chloro-2-hydroxyphenyl)cyclopent-1-enyl]pyridine-2-carboxylic acid, 4-fluorobenzyl bromide instead of 4-chlorobenzyl bromide and acetone instead of 2-butanone.

Workup

  1. customPrepared by general procedure 5

Sources & evidence

ORD record
ord-bdd8a229afc7495e917361a3de463f1c
Source dataset
uspto-grants-2007_06
Patent number
US07232821B2

Reaction notes

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