Water → HCID 69508212, compound

Participants

Reaction Steps

5-{2-[5-trifluoromethyl-2-benzyloxyphenyl]cyclopent-1-enyl}-3-aminobenzoic acid ethyl ester (90 mg, 0.18 mmol), potassium carbonate (51 mg, 0.37 mmol), ethyliodide (0.037 mL, 0.47 mmol), in 3 mL of DMF were stirred at 40° C. for 16 hrs, another 0.037 mL of ethyl iodide were added and the reaction mixture was stirred for another 4 hrs. The mixture was then poured into water and extracted with ethyl acetate (3×10 mL). The combined organic layers were dried (MgSO4), and concentrated. Purification was carried out on SPE using a gradient of iso-hexane/ethyl acetate.

Provenance & Evidence