1-(Bromomethyl)-2,4-difluorobenzene → HCID 69508091, compound

HRID 1767240Notes

Reaction equation

HRID 1767240 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[N:10][CH:9]=[C:8]([C:12]2[CH2:16][CH2:15][CH2:14][C:13]=2[C:17]2[CH:22]=[C:21]([CH3:23])[CH:20]=[CH:19][C:18]=2[OH:24])[N:7]=1)=[O:5])[CH3:2].[F:25][C:26]1[CH:33]=[C:32]([F:34])[CH:31]=[CH:30][C:27]=1[CH2:28]Br>>[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[N:10][CH:9]=[C:8]([C:12]2[CH2:16][CH2:15][CH2:14][C:13]=2[C:17]2[CH:22]=[C:21]([CH3:23])[CH:20]=[CH:19][C:18]=2[O:24][CH2:28][C:27]2[CH:30]=[CH:31][C:32]([F:34])=[CH:33][C:26]=2[F:25])[N:7]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 902971-(Bromomethyl)-2,4-difluorobenzeneHCID 136378438HCID 136378438, compound

Product 1

HCID 69508091HCID 69508091, compound

Procedure

Prepared by general procedure F(iii) but using 6-{2-[5-methyl-2-(hydroxy)phenyl]cyclopent-1-enyl}pyrazine-2-carboxylic acid ethyl ester instead of 6-{2-[5-methyl-2-(hydroxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic acid ethyl ester and 2,4-difluorobenzyl bromide instead of 4-fluorobenzyl bromide.

Workup

  1. customPrepared by general procedure F(iii)

Sources & evidence

ORD record
ord-d8c143aec84e440ea3e7371f6b29944a
Source dataset
uspto-grants-2007_06
Patent number
US07232821B2

Reaction notes

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