反应详情

温度

90 °C

Sulphuric acid (10 drops) was added to 3-bromo-5-methylbenzoic acid (1.18 g, 5.49 mmol) in ethanol (20 ml) and refluxed at 90° C. for 20 hours. After cooling, the mixture was diluted with diethyl ether/water and the organic phase washed with sodium hydrogen bicarbonate (saturated solution), dried (magnesium sulphate) and evaporated to dryness to give the title compound as a pale yellow oil (1.249 g, 94%).

1. temperatureAfter cooling
2. washthe organic phase washed with sodium hydrogen bicarbonate (saturated solution)
3. dry with materialdried (magnesium sulphate)
4. customevaporated to dryness