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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1767246Generated: November 1, 2026

Methyl Ethyl Ketone → 6-{2-[5-Fluoro-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic Acid 4-fluorobenzyl Ester

https://huagongshe.com/reaction/1767246

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl Ethyl KetoneHCID 6569—
Reactant4-Fluorobenzyl bromideHCID 68021—
ReactantHCID 135979826HCID 135979826—
SolventAcetoneHCID 180—
Product6-{2-[5-Fluoro-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic Acid 4-fluorobenzyl EsterHCID 69508097—

Reaction Steps

Prepared by general procedure 5 but using 6-{2-[5-fluoro-2-(hydroxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic acid instead of 6-{2-[5-chloro-2-(hydroxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic acid, 4-fluorobenzyl bromide instead of 4-chlorobenzyl bromide and with acetone as solvent instead of 2-butanone.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07232821B2
Source datasetuspto-grants-2007_06
ORD IDord-e9fa1eb2af334e01879280dbd78fe207
Source noteuspto-grants-2007_06