HCID 21112908, compound → HCID 69507992, compound

HRID 1767249Notes

Reaction equation

HRID 1767249 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([F:13])=[C:6]([CH:12]=1)[C:7]([O:9][CH2:10][CH3:11])=[O:8].[F:14][C:15]1[CH:37]=[CH:36][C:18]([CH2:19][O:20][C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:22]=2[C:28]2[CH2:32][CH2:31][CH2:30][C:29]=2B(O)O)=[CH:17][CH:16]=1>>[CH2:10]([O:9][C:7](=[O:8])[C:6]1[CH:12]=[C:2]([C:29]2[CH2:30][CH2:31][CH2:32][C:28]=2[C:22]2[CH:23]=[C:24]([Cl:27])[CH:25]=[CH:26][C:21]=2[O:20][CH2:19][C:18]2[CH:17]=[CH:16][C:15]([F:14])=[CH:37][CH:36]=2)[CH:3]=[CH:4][C:5]=1[F:13])[CH3:11]

Participants

3

Reactant 2

HCID 21112908HCID 21112908, compoundHCID 21113016Ethyl 5-bromo-2-fluorobenzoate

Product 1

HCID 69507992HCID 69507992, compoundYield 23%

Procedure

Prepared according to general procedure C(iii) using ethyl 5-bromo-2-fluorobenzoate and 2-(2-(4-fluorobenzyloxy)-5-chlorophenyl)cyclopentene-1-boronic acid to give the product as a colourless solid 43 mg 23%.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-41627366bb464fd785fa90a61c382d06
Source dataset
uspto-grants-2007_06
Patent number
US07232821B2

Reaction notes

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