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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1767251Generated: November 1, 2026

[5-Chloro-2-(2,4-di-fluorobenzyloxy)phenyl]boronic acid → 3-{2-[5-Chloro-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-5-methylbenzoic Acid Ethyl Ester

https://huagongshe.com/reaction/1767251

Reaction equation

Participants

RoleNameHCIDCharge
Reactant[5-Chloro-2-(2,4-di-fluorobenzyloxy)phenyl]boronic acidHCID 21112998—
Reactant3-(2-Bromocyclopent-1-enyl)-5-methylbenzoic acid ethyl esterHCID 69507739—
Product3-{2-[5-Chloro-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-5-methylbenzoic Acid Ethyl EsterHCID 69507986—

Reaction Steps

Prepared by general procedure B(iii) but using 3-(2-bromocyclopent-1-enyl)-5-methylbenzoic acid ethyl ester instead of 3-(2-bromo-cyclopent-1-enyl)-6-methyl benzoic acid ethyl ester and using [5-chloro-2-(2,4-di-fluorobenzyloxy)phenyl]boronic acid instead of (5-chloro-2-benzyloxyphenyl)boronic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07232821B2
Source datasetuspto-grants-2007_06
ORD IDord-01f31233d00a4e859b45cb449e583844
Source noteuspto-grants-2007_06