Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1767258Generated: October 25, 2026

Boronic Acid → 3-{2-[5-Trifluoromethyl-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-5-fluorobenzoic Acid Ethyl Ester

https://huagongshe.com/reaction/1767258

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBoronic AcidHCID 61668—
Reactant2-(2,4-Difluorobenzyloxy)-5-trifluoromethylphenylboronic acidHCID 21112905—
ReactantEthyl 3-(2-bromocyclopent-1-enyl)-5-fluorobenzoateHCID 57862528—
Product3-{2-[5-Trifluoromethyl-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-5-fluorobenzoic Acid Ethyl EsterHCID 86601297—

Reaction Steps

Prepared by general procedure B(iii) but using 3-(2-bromocyclopent-1-enyl)-5-fluorobenzoic acid ethyl ester instead of 3-(2-bromo-cyclopent-1-enyl)-6-methyl benzoic acid ethyl ester and using [5-trifluoromethyl-2-(2,4-di-fluorobenzyloxy)phenyl]boronic acid instead of 5-chloro-2-benzyloxyphenyl)boronic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07232821B2
Source datasetuspto-grants-2007_06
ORD IDord-f581f6f1020140aeb4ebec658f6058ff
Source noteuspto-grants-2007_06