HCID 21112914, compound → HCID 69508102, compound

HRID 1767260Notes

Reaction equation

HRID 1767260 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][C:10]=1[C:19]1[CH2:23][CH2:22][CH2:21][C:20]=1B(O)O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:27]([O:29][C:30](=[O:39])[C:31]1[C:36]([F:37])=[CH:35][CH:34]=[C:33](Br)[CH:32]=1)[CH3:28]>>[CH2:27]([O:29][C:30](=[O:39])[C:31]1[C:36]([F:37])=[CH:35][CH:34]=[C:33]([C:20]2[CH2:21][CH2:22][CH2:23][C:19]=2[C:10]2[CH:11]=[C:12]([C:15]([F:18])([F:17])[F:16])[CH:13]=[CH:14][C:9]=2[O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH:32]=1)[CH3:28]

Participants

3

Reactant 2

HCID 21112914HCID 21112914, compoundHCID 21113016Ethyl 5-bromo-2-fluorobenzoate

Product 1

HCID 69508102HCID 69508102, compound

Procedure

Prepared by general procedure C(iii) but using 2-(2-benzyloxy-5-trifluoromethylphenyl)cyclopentene-1-boronic acid instead of 2-(2-benzyloxy-5-chlorophenyl)cyclopentene-1-boronic acid and 3-bromo-6-fluorobenzoic acid ethyl ester instead of 2-chloropyrimidine-4-carboxylic acid methyl ester.

Workup

  1. customPrepared by general procedure C(iii)

Sources & evidence

ORD record
ord-efa382edc85a4b3fa851e6e46eb331ff
Source dataset
uspto-grants-2007_06
Patent number
US07232821B2

Reaction notes

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