4-Bromo-2-fluorobenzoic acid → 6-[4-(4-Bromo-2-fluorobenzoyl)piperazin-1-yl]-5-methylnicotinonitrile
Reaction equation
[Br:1][c:2]1[cH:3][c:4]([F:11])[c:5]([C:6](=[O:7])[OH:8])[cH:9][cH:10]1.[CH3:12][c:13]1[c:14]([N:21]2[CH2:22][CH2:23][NH:24][CH2:25][CH2:26]2)[n:15][cH:16][c:17]([C:18]#[N:19])[cH:20]1>>[Br:1][c:2]1[cH:3][c:4]([F:11])[c:5]([C:6](=[O:8])[N:24]2[CH2:23][CH2:22][N:21]([c:14]3[c:13]([CH3:12])[cH:20][c:17]([C:18]#[N:19])[cH:16][n:15]3)[CH2:26][CH2:25]2)[cH:9][cH:10]1Participants
3
Sources & evidence
- ORD record
- ord-ec848532fcf24eaeba104fe01cf81382
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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