Morpholine → HCID 22258735, compound

HRID 1767401Notes

Reaction equation

HRID 1767401 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[N:20]=[C:19]([O:21][CH2:22][C:23]([NH2:25])=[O:24])[C:18]([C:26]#[N:27])=[C:17](S(C)=O)[CH:16]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:31]1[CH2:36][CH2:35][O:34][CH2:33][CH2:32]1>O>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[N:20]=[C:19]([O:21][CH2:22][C:23]([NH2:25])=[O:24])[C:18]([C:26]#[N:27])=[C:17]([N:31]2[CH2:36][CH2:35][O:34][CH2:33][CH2:32]2)[CH:16]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 22258909HCID 22258909, compound

Product 1

HCID 22258735HCID 22258735, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
130 °C

Procedure

A mixture of 2-{[6-[2-(benzyloxy)phenyl]-3-cyano-4-(methylsulfinyl)-2-pyridinyl]oxy}acetamide (300 mg, 0.71 mmol) and morpholine (1.0 mL) was stirred at 130° C. for 1 hr, and then water was added. The resulting precipitates were collected by filtration and dried under reduced pressure to give 2-{[6-[2-(benzyl-oxy)phenyl]-3-cyano-4-(4-morpholinyl)-2-pyridinyl]oxy}acetamide as a yellow solid (304 mg, yield; 96%).

Workup

  1. customThe resulting precipitates
  2. filtrationwere collected by filtration
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-e40295a36b2745688a450f06c47e982d
Source dataset
uspto-grants-2007_06
Patent number
US07232909B2

Reaction notes

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