6-Methoxy-3-nitropyridine-2-acetonitrile → 5-methoxy-1H-pyrrolo[3,2-b]pyridine

HRID 1767543노트

반응식

HRID 1767543 반응식
[CH3:1][O:2][C:3]1[N:8]=[C:7]([CH2:9][C:10]#N)[C:6]([N+:12]([O-])=O)=[CH:5][CH:4]=1>C(O)C.[Pd]>[CH3:1][O:2][C:3]1[N:8]=[C:7]2[CH:9]=[CH:10][NH:12][C:6]2=[CH:5][CH:4]=1

참가 물질

4

반응물 1

HCID 6395106-Methoxy-3-nitropyridine-2-acetonitrile

생성물 1

HCID 53243695-methoxy-1H-pyrrolo[3,2-b]pyridine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

Under a hydrogen pressure of 45 psi, 17.70 g (91.7 mmol) of the compound obtained in Step A and 2.5 g of palladium-on-carbon suspended in 300 ml of ethanol are stirred for 5 hours at room temperature. After filtration over Celite and evaporation, the residue is purified over silica gel (eluant:petroleum ether/ethyl acetate, 4:1) to yield the title product in the form of a brown solid.

후처리

  1. filtrationAfter filtration
  2. customover Celite and evaporation
  3. customthe residue is purified over silica gel (eluant:petroleum ether/ethyl acetate, 4:1)

출처 및 근거

ORD 기록
ord-dec12f5cb47a4acfad4b5c4dbec8dddf
출처 데이터셋
uspto-grants-2007_06
특허 번호
US07235550B2

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