Sodium Hydroxide → 4-(2-Methoxy-6H-pyrido[2',3':4,5]pyrrolo[2,1-a]isoindol-11-yl)-butanoic acid

HRID 1767548Notes

Reaction equation

HRID 1767548 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[N:10]3[CH2:11][C:12]4[C:17]([C:9]3=[C:8]([CH:18]=[CH:19][CH2:20][C:21]([O:23]CC)=[O:22])[C:7]=2[N:26]=1)=[CH:16][CH:15]=[CH:14][CH:13]=4.[OH-].[Na+]>C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[N:10]3[CH2:11][C:12]4[C:17]([C:9]3=[C:8]([CH2:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22])[C:7]=2[N:26]=1)=[CH:16][CH:15]=[CH:14][CH:13]=4

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69419312Ethyl 4-(2-methoxy-6H-pyrido[2',3':4,5]pyrrolo[2,1-a]isoindol-11-yl)-3-butenoate

Product 1

HCID 187582074-(2-Methoxy-6H-pyrido[2',3':4,5]pyrrolo[2,1-a]isoindol-11-yl)-butanoic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The ester obtained in Step A is placed in 150 ml of ethanol in the presence of 40 ml of 2N sodium hydroxide solution. The title acid is isolated after stirring at room temperature and then refluxing.

Sources & evidence

ORD record
ord-b7ebdac4278f4b34a38d3dbadb76cf00
Source dataset
uspto-grants-2007_06
Patent number
US07235550B2

Reaction notes

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