HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 1,2,3,5,10,10a-Hexahydrobenzo[e]pyrrolo[1,2-b]-1,2,4-thiadiazine-5,5-dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-Aminobenzenesulfonamide | HCID 72894 | — |
| Reactant | 4-Chlorobutyryl chloride | HCID 78370 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | 1,2,3,5,10,10a-Hexahydrobenzo[e]pyrrolo[1,2-b]-1,2,4-thiadiazine-5,5-dioxide | HCID 9794515 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
2-Aminobenzenesulfonamide was used as starting material for the following transformation sequence: Method E (using 4-chlorobutanoyl chloride. The reaction mixture was NOT subjected to NaOH catalyzed ring closure, but dissolved in H2SO4 and heated at 100° C. for 72 h and precipitated on ice). M.p. 149–154° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07235548B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-6e78fbb4760445718efa725f1d56e3f4 |
| Source note | uspto-grants-2007_06 |