Triethylamine → HCID 178504983, compound

Participants

Reaction Steps

A stirred solution of 7-amino-3-cyclohexyl-1,2-dihydro-1,2,4-benzothiadiazine-1,1-dioxide (1 g; 3.6 mmol) and triethylamine (1.2 ml; 8 mmol) in dry THF (25 ml) was added methanesulfonylchloride (0.6 ml; 8 mmol) and stirred at rt. for 2 h. The reaction mixture was evaporated to dryness, resuspended in H2O/EtOAc and filtered. The filtrate was adsorbed onto silica gel. Column chromatography (CH2Cl2:acetone=9:1) gave 210 mg of product.

Provenance & Evidence