Acetic Acid → HCID 178432136, compound

HRID 1767645Notes

Reaction equation

HRID 1767645 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:10])=[O:9].[CH3:12][C:13](O)=O>>[CH3:12][C:13]1[NH:11][S:8](=[O:9])(=[O:10])[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[N:1]=1

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 728942-Aminobenzenesulfonamide

Product 1

HCID 178432136HCID 178432136, compoundYield 91%

Procedure

2-Aminobenzenesulfonamide (17.2 g; 100 mmol) was refluxed in AcOH for 5 days. The precipitate formed was isolated by filtration and washed with water to give 17.8 g (91%) of 3-methyl-1,2-dihydro-1,2,4-benzothiadiazine-1,1-dioxide. 3-Methyl-1,2-dihydro-1,2,4-benzothiadiazine-1,1-dioxide was transformed by Method A (using dimethylamine as amine). M.p. 260–261° C.

Workup

  1. customThe precipitate formed
  2. customwas isolated by filtration
  3. washwashed with water

Sources & evidence

ORD record
ord-cfdcec271d6b4666ad8752d0f03ab087
Source dataset
uspto-grants-2007_06
Patent number
US07235548B2

Reaction notes

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