反应详情

A stirred suspension of 2-amino-4-chloro-5-sulfamoylbenzenesulfonamide (11.4 g; 40 mmol) and 10% Pd/C (750 mg) in EtOH (300 ml) was hydrogenated at 1 bar until hydrogen consumption ceased (24 h). The reaction mixture was evaporated to dryness, resuspended in THF and filtered through celite. The filtrate was evaporated to dryness and the isolated solid washed with boiling EtOAc (2×150 ml) to give 9.58 g (95%) product.

1. customwas hydrogenated at 1 bar until hydrogen consumption
2. custom(24 h)
3. customThe reaction mixture was evaporated to dryness
4. filtrationfiltered through celite
5. customThe filtrate was evaporated to dryness
6. washthe isolated solid washed with boiling EtOAc (2×150 ml)