Cyclohexanecarboxaldehyde → 5-Bromo-3-cyclohexyl-7-sulfamoyl-1,2,3,4-tetrahydro-1,2,4-benzothiadiazine-1,1-dioxide

HRID 1767658Notes

Reaction equation

HRID 1767658 reaction equation
[NH2:1][C:2]1[C:7]([Br:8])=[CH:6][C:5]([S:9](=[O:12])(=[O:11])[NH2:10])=[CH:4][C:3]=1[S:13]([NH2:16])(=[O:15])=[O:14].[CH:17]1([CH:23]=O)[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1>>[Br:8][C:7]1[C:2]2[NH:1][CH:23]([CH:17]3[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]3)[NH:16][S:13](=[O:15])(=[O:14])[C:3]=2[CH:4]=[C:5]([S:9](=[O:11])(=[O:12])[NH2:10])[CH:6]=1

Participants

3

Reactant 2

HCID 16275CyclohexanecarboxaldehydeHCID 22323981HCID 22323981, compound

Product 1

HCID 223240905-Bromo-3-cyclohexyl-7-sulfamoyl-1,2,3,4-tetrahydro-1,2,4-benzothiadiazine-1,1-dioxide

Procedure

2-Amino-3-bromo-5-sulfamoylbenzenesulfonamide was transformed by Method G (using cyclohexanecarboxaldehyde). M.p. 254–258° C.

Sources & evidence

ORD record
ord-9c5a3b60afdb455f838e185b4d681b63
Source dataset
uspto-grants-2007_06
Patent number
US07235548B2

Reaction notes

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