HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → N-(2-Sulfamoylphenyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Aminobenzenesulfonamide | HCID 72894 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(2-Sulfamoylphenyl)acetamide | HCID 12489724 | 79.3% |
Reaction Steps
A stirred solution of 2-aminobenzenesulfonamide (1.72 g; 10 mmol) and triethylamine (1.53 ml; 11 mmol) in THF (25 ml) at 0° C. was added AcCl (0.85 ml; 12 mmol) and left with stirring at rt. over night. The reaction mixture was filtered and adsorbed onto silica. Column chromatography gave 1.7 g (79%) product. M.p. 153.5–155.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07235548B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-14ab805bd29d4be492cf6383b98004eb |
| Source note | uspto-grants-2007_06 |