HCID 69519934, compound → HCID 69520018, compound

HRID 1767739Notes

Reaction equation

HRID 1767739 reaction equation
[C:1]([NH:7][C:8]1[N:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][N:9]=1)(=[O:6])[CH2:2][CH2:3][CH2:4][CH3:5]>C(O)C.[Pt]=O>[C:1]([NH:7][C:8]1[N:13]=[CH:12][C:11]([NH2:14])=[CH:10][N:9]=1)(=[O:6])[CH2:2][CH2:3][CH2:4][CH3:5]

Participants

4

Reactant 1

HCID 69519934HCID 69519934, compound

Product 1

HCID 69520018HCID 69520018, compoundYield 55%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

Platinum oxide (50 mg, 0.22 mmol) was added to a solution of 2-(N-pentanoyl)amino-5-nitropyrimidine (650 mg, 2.9 mmol) in ethanol (100 ml) at ambient temperature and the reaction stirred for 1 hour under an atmosphere of hydrogen. The reaction was filtered through a pad of celite and the solvents were evaporated in vacuo. Trituration with diethylether and drying yielded 2-(N-pentanoyl)amino-5-aminopyrimidine (307 mg, 55% yield) as brown solid:

Workup

  1. filtrationThe reaction was filtered through a pad of celite
  2. customthe solvents were evaporated in vacuo
  3. dry with materialTrituration with diethylether and drying

Sources & evidence

ORD record
ord-e6370b5446774875963e78ff007ad24f
Source dataset
uspto-grants-2007_06
Patent number
US07235559B1

Reaction notes

Loading…