5-Nitropyrimidin-2-amine → HCID 69521039, compound

Participants

Reaction Steps

Cyclopentanoyl chloride (946 mg, 7.14 mmol) was added dropwise to a stirred suspension of 2-amino-5-nitropyrimidine (1.0 g, 7.14 mmol) in pyridine (10 ml) and the reaction was heated at reflux for 4 hours under an inert atmosphere. The reaction mixture was cooled then stirred in 2N hydrochloric acid (100 ml) and the resulting solid collected by suction filtration. Purification by flash chromatography on silica gel, eluting with 2% methanol in dichloromethane, yielded 2-(N-cyclopentanoyl)amino-5-nitropyrimidine (812 mg, 48% yield) as an beige solid:

Provenance & Evidence