HCID 69521039, compound → HCID 69519693, compound

HRID 1767741Notes

Reaction equation

HRID 1767741 reaction equation
[CH:1]1([C:6]([NH:8][C:9]2[N:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][N:10]=2)=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1>C(O)C.[Pt]=O>[CH:1]1([C:6]([NH:8][C:9]2[N:14]=[CH:13][C:12]([NH2:15])=[CH:11][N:10]=2)=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 1

HCID 69521039HCID 69521039, compound

Product 1

HCID 69519693HCID 69519693, compoundYield 73.2%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

Platinum oxide (50 mg, 0.22 mmol) was added to a solution 2-(N-cyclopentanoyl)amino-5-nitropyrimidine (808 mg, 3.42 mmol) in ethanol (100 ml) at ambient temperature and the reaction stirred for 1 hour under an atmosphere of hydrogen. The reaction was filtered through a pad of celite and the solvents were evaporated in vacuo. Trituration with diethylether and drying yielded 2-(N-cyclopentanoyl)amino-5-aminopyrimidine (516 mg, 73% yield) as brown solid:

Workup

  1. filtrationThe reaction was filtered through a pad of celite
  2. customthe solvents were evaporated in vacuo
  3. dry with materialTrituration with diethylether and drying

Sources & evidence

ORD record
ord-a70c25bdb19d4894b552119ce5634158
Source dataset
uspto-grants-2007_06
Patent number
US07235559B1

Reaction notes

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