Hydrochloric Acid → 4-[2-(Aminooxy)ethyl]morpholine dihydrochloride

HRID 1767791Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1767791
C(OC(=O)[NH:7][O:8][CH2:9][CH2:10][N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)(C)(C)C.O1CCOCC1.[ClH:24]>CO>[ClH:24].[ClH:24].[N:11]1([CH2:10][CH2:9][O:8][NH2:7])[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1

Komponenten

5

Edukt 3

HCID 313Hydrochloric Acid2×HCID 312751,4-DioxaneHCID 85868160HCID 85868160, Verbindung

Produkt 1

HCID 219787654-[2-(Aminooxy)ethyl]morpholine dihydrochlorideAusbeute 78 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of (2-morpholin-4-yl-ethoxy)-carbamic acid tert-butyl ester (118 mg, 0.48 mmol) in MeOH (1 mL) is added 4 M dioxane solution of HCl (2.4 mL, 9.60 mmol) at room temperature. The resulting solution is stirred for 16 hours at room temperature. After addition of additional HCl (2.4 mL) followed by stirring for 4 hours, the reaction mixture is concentrated in vacuo to give yellow solids (82 mg, 78%).

Aufarbeitung

  1. stirringby stirring for 4 hours
  2. concentrationthe reaction mixture is concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-459497adbeb3424b95a80df2f9b22524
Quelldatensatz
uspto-grants-2007_06
Patentnummer
US07235537B2

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