Sodium Hydroxide → [Rac]-(4-{2-methyl-1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-propoxy}-indol-1-yl)-acetic acid
반응식
C([O:5][C:6](=[O:38])[CH2:7][N:8]1[C:16]2[C:11](=[C:12]([O:17][CH:18]([C:22]3[S:26][C:25]([C:27]4[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:35])[F:34])=[CH:29][CH:28]=4)=[N:24][C:23]=3[CH3:37])[CH:19]([CH3:21])[CH3:20])[CH:13]=[CH:14][CH:15]=2)[CH:10]=[CH:9]1)(C)(C)C.[OH-].[Na+]>>[CH3:20][CH:19]([CH3:21])[CH:18]([C:22]1[S:26][C:25]([C:27]2[CH:28]=[CH:29][C:30]([C:33]([F:35])([F:36])[F:34])=[CH:31][CH:32]=2)=[N:24][C:23]=1[CH3:37])[O:17][C:12]1[CH:13]=[CH:14][CH:15]=[C:16]2[C:11]=1[CH:10]=[CH:9][N:8]2[CH2:7][C:6]([OH:38])=[O:5]참가 물질
3
실험 절차
In analogy to the procedure described in example 2 c], [rac]-(4-{2-methyl-1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-propoxy}-indol-1-yl)-acetic acid tert-butyl ester was treated with NaOH to obtain [rac]-(4-{2-methyl-1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-propoxy}-indol-1-yl)-acetic acid as yellow oil.
출처 및 근거
- ORD 기록
- ord-10b12361767b4b02b12b57953feaa692
- 출처 데이터셋
- uspto-grants-2007_06
- 특허 번호
- US07235572B2
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