HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → [6-(Tert-butyl-dimethyl-silanyloxy)-indol-1-yl]-acetic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | tert-Butyl bromoacetate | HCID 79177 | — |
| Reactant | 6-((tert-butyldimethylsilyl)oxy)-1H-indole | HCID 22250816 | — |
| Product | [6-(Tert-butyl-dimethyl-silanyloxy)-indol-1-yl]-acetic acid tert-butyl ester | HCID 69279688 | — |
Reaction Steps
In analogy to the procedure described in example 1 b], 6-(tert-butyl-dimethyl-silanyloxy)-1H-indole was reacted with bromo-acetic acid tert-butyl ester in the presence of sodium hydride to obtain [6-(tert-butyl-dimethyl-silanyloxy)-indol-1-yl]-acetic acid tert-butyl ester as colorless liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07235572B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-3f9a9c82fc4944efbdbec4a805b6a83b |
| Source note | uspto-grants-2007_06 |