HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → (3-Chloro-6-{2-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethoxy}-indol-1-yl)-acetic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Di-tert-butyl azodicarboxylate | HCID 97268 | — |
| Reactant | 2-[4-Methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethanol | HCID 22647583 | — |
| Reactant | tert-Butyl (3-chloro-6-hydroxy-1H-indol-1-yl)acetate | HCID 69283057 | — |
| Product | (3-Chloro-6-{2-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethoxy}-indol-1-yl)-acetic acid tert-butyl ester | HCID 69279677 | — |
Reaction Steps
In analogy to the procedure described in example 3 c], (3-chloro-6-hydroxy-indol-1-yl)-acetic acid tert-butyl ester was reacted with 2-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethanol (example 5 c]) in the presence of triphenylphosphine and di-tert-butyl azodicarboxylate to yield (3-chloro-6-{2-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethoxy}-indol-1-yl)-acetic acid tert-butyl ester as light yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07235572B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-9ea37af76f7744169ac7e6bab9fa9230 |
| Source note | uspto-grants-2007_06 |