Triphenylphosphine → HCID 69280405, compound

Participants

Reaction Steps

In analogy to the procedure described in example 3 c], (6-hydroxy-indol-1-yl)-acetic acid tert-butyl ester (example 6 b]) was reacted with 2-[5-methyl-2-(4-trifluoromethoxy-phenyl)-thiazol-4-yl]-ethanol {prepared from 4-methyl-2-(4-trifluoromethoxy-phenyl)-thiazole-5-carboxylic acid ethyl ester (PCT Int. Appl. (2001), WO 2001040207 A1) in analogy to the procedures described in examples 19 b] to 19 f]} in the presence of triphenylphosphine and di-tert-butyl azodicarboxylate to yield (6-{2-[4-methyl-2-(4-trifluoromethoxy-phenyl)-thiazol-5-yl]-ethoxy}-indol-1-yl)-acetic acid tert-butyl ester as yellow oil.

Provenance & Evidence