HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → HCID 69279707, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 5-Chloromethyl-4-methyl-2-(4-trifluoromethyl-phenyl)-thiazole | HCID 2783006 | — |
| Reactant | tert-Butyl (6-hydroxy-1H-indol-1-yl)acetate | HCID 69283069 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 69279707 | HCID 69279707 | — |
Reaction Steps
In analogy to the procedure described in example 1 a], (6-hydroxy-indol-1-yl)-acetic acid tert-butyl ester (example 6 b]) was treated with 5-chloromethyl-4-methyl-2-(4-trifluoromethyl-phenyl)-thiazole [PCT Int. Appl. (2002), WO 0292590 A1] in the presence of cesium carbonate and potassium iodide in acetone for 14 h at reflux temperature to give the title compound as yellow liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07235572B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-e31e358bcbed4a98b03aada81f8a0374 |
| Source note | uspto-grants-2007_06 |