HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → [6-(Tert-butyl-dimethyl-silanyloxy)-3-chloro-indol-1-yl]-acetic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | tert-Butyl bromoacetate | HCID 79177 | — |
| Reactant | 6-{[tert-Butyl(dimethyl)silyl]oxy}-3-chloro-1H-indole | HCID 23614510 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | [6-(Tert-butyl-dimethyl-silanyloxy)-3-chloro-indol-1-yl]-acetic acid tert-butyl ester | HCID 69283059 | — |
Reaction Steps
In analogy to the procedure described in example 1 b], 6-(tert-butyl-dimethyl-silanyloxy)-3-chloro-1H-indole was reacted with bromo-acetic acid tert-butyl ester in the presence of cesium carbonate in DMF to obtain [6-(tert-butyl-dimethyl-silanyloxy)-3-chloro-indol-1-yl]-acetic acid tert-butyl ester as yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07235572B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-937796f1d19f494794a671b35c2bfb57 |
| Source note | uspto-grants-2007_06 |