HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → 3-methyl-6-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 5-Chloromethyl-4-methyl-2-(4-trifluoromethyl-phenyl)-thiazole | HCID 2783006 | — |
| Reactant | 6-Hydroxyskatole | HCID 13662595 | — |
| Product | 3-methyl-6-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-1H-indole | HCID 23614496 | — |
Reaction Steps
In analogy to the procedure described in example 27 e], 3-methyl-1H-indol-6-ol was reacted with 5-chloromethyl-4-methyl-2-(4-trifluoromethyl-phenyl)-thiazole [PCT Int. Appl. (2002), WO 0292590 A1] in the presence of cesium carbonate to give 3-methyl-6-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-1H-indole as light brown crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07235572B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-46d5a25735e148c3a3a255a48e1869ed |
| Source note | uspto-grants-2007_06 |