反应详情

A mixture of benzofuran-3 (2H)-one (1.34 g, 10 mmol) and (carboxymethylene) triphenylphosphorane (5.22 g, 15 mmol) was refluxed in toluene (100 ml) for 48 hrs. At the end, reaction mixture was concentrated and loaded over a silica-gel column. The column was eluted with hexane (500 ml) and later with 25% ethyl acetate. The product, ethyl(-1-benzofuran-3-yl)acetate, was obtained as a white oil. Yield: 2.0 g (98%); 205 (M+H).

1. customAt the end, reaction mixture
2. concentrationwas concentrated
3. washThe column was eluted with hexane (500 ml) and later with 25% ethyl acetate