Aluminium lithium hydride → HCID 18184294, compound

Participants

Reaction Steps

To a stirred suspension of LiAlH4 (200 mg, excess) in THF at 0° C., ethyl(5-fluoro-1-benzofuran-3-yl)acetate (1.11 g, 5 mmol) in THF (20 mL) was added slowly. After the addition, the reaction mixture was stirred at room temperature for 1 hr and quenched with saturated NH4Cl solution. The product was extracted with chloroform and washed well with water. It was dried over anhydrous MgSO4; filtered and concentrated. The product, 2-(5-fluoro-1-benzofuran-3-yl)ethanol obtained as white oil and was pure enough to be taken to the next step without purification. Yield: 820 mg (91%); 181 (M+H).

Provenance & Evidence