1H-Indole, 3-[1-(2-naphtho[1,2-b]furan-3-ylethyl)-4-piperidinyl]- → HCID 86595773, compound

Participants

Reaction Steps

3-{1-(2-naphtho[1,2-b]furan-3-yl-ethyl)-piperidin-4-yl]-1H-indole (197 mg, 0.5 mmol) obtained from step 6, was hydrogenated over 10% Pd/C in ethanol at 40 psi pressure. At the end, reaction mixture was filtered through a pad of celite and concentrated. The product obtained was purified by silica-gel column chromatography by eluting it with 70% ethyl acetate:hexane 3-{1-(2-naphtho[1,2-b]furan-3-yl-ethyl)-piperidin-4-yl]-1H-indole was isolated as yellow solid; Yield: 160 mg (81%); 395 (M+H); 1H NMR: δ 8.30 (1H, d, J=8 Hz), 7.99 (1H, s, NH), 7.94(1H, d, J=8 Hz), 7.67(4H, m), 7.58(1H, t, J=8 Hz), 7.48(1H, t, J=8 Hz), 7.38(1H, d, J=8 Hz), 7.20(1H, t, J=8 Hz), 7.13(1H, t, J=8 Hz), 7.0(1H, s), 3.21(2H, d, J=12 Hz), 3.04(1H, m), 2.90(1H, m), 2.84(2H, m), 2.29(2H, m), 2.13(2H, d, J=12 Hz), 1.90(2H, m, J=12 Hz).

Provenance & Evidence