反应详情

A mixture of 3.65 g (15.0 mmol) 1-(4-bromo-butyl)-4-methoxy-benzene, 2.52 g (22.5 mmol) 2-(1H-imidazol-2-yl)-ethanol, 2.74 g (16.5 mmol) potassium iodide, 0.90 g (22.5 mmol) sodium hydroxide and 15 ml 2-methyl-2-butanol was heated to reflux for 12 h. Solvents were distilled off, the residue dissolved in toluene and washed with water. After drying over Na2SO4 and removal of solvents in vacuo the residue was stirred with 7 ml ethyl acetate, isolated by filtration, washed with ethyl acetate and dried. Yield 2.41 g (59%).

1. temperaturewas heated
2. temperatureto reflux for 12 h
3. distillationSolvents were distilled off
4. dissolutionthe residue dissolved in toluene
5. washwashed with water
6. dry with materialAfter drying over Na2SO4 and removal of solvents in vacuo the residue
7. customisolated by filtration
8. washwashed with ethyl acetate
9. customdried