Water → HCID 11387413, compound

Participants

Reaction Steps

14 mg (0.50 mmol) 95% sodium hydride were given to a solution of 126 mg (0.50 mmol) 4-(2-[1,2,3]Triazol-1-yl-ethanesulfinylmethyl)-phenol in 3.0 ml DMF and stirred for 15 min. 173 mg (0.50 mmol) 4-chloromethyl-2-[2-(4-pentafluorosulfanyl-phenyl)-vinyl]-oxazole were added and stirring continued at r.t. overnight. After addition of 6 ml water the resulting precipitate was washed with water (2×), water/methanol 1:1 (2×), ethyl acetate/n-heptane 3:1 (1×), little ethyl acetate (1×), diethyl ether (1×) and dried in vacuum at 40° C. Further purification by chromatography on silica gel (eluent:ethyl acetate/methanol 15:1) and stirring of the isolated product with little ether and ethyl acetate and drying gave 48 mg (17%) white powder.

Provenance & Evidence