反应详情

A solution of 4-chloromethyl-2-[2-(4-pentafluorosulfanyl-phenyl)-vinyl]-oxazole (0.30 g, 1.28 mmol) and sodium 4-bromobenzenesulfinate (0.717 g, 2.57 mmol) in N,N-dimethyl formamide (20 ml) was stirred for 3 h at 60° C. After cooling the mixture was poured onto water, extracted with ethyl acetate (3×50 ml), the combined organic layers were washed with water, dried over sodium sulfate, concentrated in vacuo and crystallized from ether/isohexane yielding 4-(4-bromo-benzenesulfonylmethyl)-2-[2-(4-pentafluorosulfanyl-phenyl)-vinyl]-oxazole as white crystalline product. Yield 0.345 g (51%).

1. temperatureAfter cooling the mixture
2. additionwas poured onto water
3. extractionextracted with ethyl acetate (3×50 ml)
4. washthe combined organic layers were washed with water
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated in vacuo
7. customcrystallized from ether/isohexane