HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1768128Generated: November 2, 2026
Water → (RS)-1-(4-Benzyloxy-phenyl)-2-oxo-pyrrolidine-3-carbonitrile
https://huagongshe.com/reaction/1768128
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | (RS)-1-(4-benzyloxy-phenyl)-3-bromo-pyrrolidin-2-one | HCID 23614761 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (RS)-1-(4-Benzyloxy-phenyl)-2-oxo-pyrrolidine-3-carbonitrile | HCID 9839008 | 13% |
Reaction Steps
300 mg (0.87 mmol) of (RS)-1-(4-benzyloxy-phenyl)-3-bromo-pyrrolidin-2-one is dissolved in 5 ml N,N-dimethylformamide. 64 mg (1.3 mmol) sodium cyanide and 13 mg (0.09 mmol) sodium iodide are added and the suspension stirred for 10 min. at 120° C. The reaction mixture is treated with water and extracted with ethyl acetate to yield 33 mg (13%) of a colorless solid. MS: m/e=293.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07235581B2 |
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| Source dataset | uspto-grants-2007_06 |
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| ORD ID | ord-022d0db5395449bb9bc685655654da17 |
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| Source note | uspto-grants-2007_06 |
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