Ammonia → HCID 10359133, compound

HRID 1768139Notes

Reaction equation

HRID 1768139 reaction equation
[F:1][C:2]1[CH:24]=[CH:23][C:5]([CH2:6][O:7][C:8]2[CH:13]=[CH:12][C:11]([N:14]3[CH2:18][CH2:17][CH:16]([C:19](O)=[O:20])[C:15]3=[O:22])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[NH3:25]>>[F:1][C:2]1[CH:24]=[CH:23][C:5]([CH2:6][O:7][C:8]2[CH:13]=[CH:12][C:11]([N:14]3[CH2:18][CH2:17][CH:16]([C:19]([NH2:25])=[O:20])[C:15]3=[O:22])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 23614752HCID 23614752, compound

Product 1

HCID 10359133HCID 10359133, compound

Procedure

The title compound is prepared in analogy to Example 3d) from (RS)-1-[4-(4-fluoro-benzyloxy)-phenyl]-2-oxo-pyrrolidine-3-carboxylic acid and ammonia. Yield: 18% of a brownish solid. MS: m/e=329.3 (M++H).

Sources & evidence

ORD record
ord-77e1949c3f784ba2a25bba9cc6cd9b50
Source dataset
uspto-grants-2007_06
Patent number
US07235581B2

Reaction notes

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