Hydrochloric Acid → HCID 69491837, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 137 mg (0.36 mmol) of (S)-[1-(4-benzyloxy-phenyl)-2-oxo-pyrrolidin-3-yl]-carbamic acid tert-butyl ester in 2 ml of dioxane is treated with 0.3 ml of hydrochloric acid (37%). The solution is warmed to 45° C. for 1 h forming a white suspension. For the working-up, the reaction mixture is evaporated under reduced pressure and the solid residue is triturated with a small volume of methanol. After filtration and drying, 94 mg of (S)-3-amino-1-(4-benzyloxy-phenyl)-pyrrolidin-2-one hydrochloride (82% of theory) are obtained as a white solid. MS: m/e=283 (M+H)+.

Provenance & Evidence