Acetic Anhydride → HCID 10471701, compound

HRID 1768150Notes

Reaction equation

HRID 1768150 reaction equation
[NH2:1][C@H:2]1[CH2:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[CH:16]=3)=[CH:9][CH:8]=2)[C:3]1=[O:22].[C:23](OC(=O)C)(=[O:25])C>C(O)=O>[F:21][C:17]1[CH:16]=[C:15]([CH:20]=[CH:19][CH:18]=1)[CH2:14][O:13][C:10]1[CH:9]=[CH:8][C:7]([N:4]2[CH2:5][CH2:6][C@H:2]([NH:1][CH:23]=[O:25])[C:3]2=[O:22])=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 69490882HCID 69490882, compound

Product 1

HCID 10471701HCID 10471701, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

In an analogous manner to that described in Example 12, the reaction of (S)-3-amino-1-[4-(3-fluoro-benzyloxy)-phenyl]-pyrrolidin-2-one with a mixture of acetic anhydride and formic acid yields the title compound as a white solid; MS: m/e=329 (M+H)+.

Sources & evidence

ORD record
ord-e03b84cf3bc749bdb92e7c9d9331ca68
Source dataset
uspto-grants-2007_06
Patent number
US07235581B2

Reaction notes

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